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pentobarbital will lessen the extent or effect of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration. Powerful or average CYP3A inducers may well lower cobimetinib systemic exposure by >eighty% and lessen its efficacy.pentobarbital will lower the extent or outcome of buspirone by

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